| Identification | Back Directory | [Name]
6-(2-AMINOPHENOXY)-1,2-BENZOTHIAZOL-3-AMINE DIHYDROCHLORIDE | [CAS]
613263-00-6 | [Synonyms]
M62812
6-(2-AMINOPHENOXY)-1,2-BENZOTHIAZOL-3-AMINE DIHYDROCHLORIDE
6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride | [Molecular Formula]
C13H12ClN3OS | [MDL Number]
MFCD30179737 | [MOL File]
613263-00-6.mol | [Molecular Weight]
293.77 |
| Hazard Information | Back Directory | [Uses]
M62812 is a toll-like receptor 4 (TLR4) transduction inhibitor and also suppresses endothelial cell and leukocyte activation, preventing lethal septic shock in mice. | [in vivo]
M62812 (i.v.; 10-20 mg/kg; single dose) is protective and reduces inflammatory and coagulation parameters in a D-galactosamine-sensitized endotoxin shock mouse model[1].
M62812 (i.v.; 20 mg/kg; once a day for three days) prevents mice from lethality in a murine cecal ligation and puncture model[1].
| Animal Model: | D-galactosamine-sensitized endotoxin shock mouse model[1] | | Dosage: | 10-20 mg/kg | | Administration: | Intravenous administration (i.v.) | | Result: | Prevented elevation of TNF-α, IL-6, soluble E-selectin, thrombin/antithrombin complexes and glutamic pyruvic transaminase activity at 20 mg/kg.
Prolonged survival in a d-galactosamine-sensitized endotoxin shock mouse model.
|
| Animal Model: | Cecal ligation and puncture mouse model[1] | | Dosage: | 20 mg/kg | | Administration: | Intravenous administration (i.v.); once a day for three days | | Result: | Reduced mortality in a murine cecal ligation and puncture model.
|
| [storage]
Store at -20°C |
|
|