| Identification | Back Directory | [Name]
1-[2,4-Dihydroxy-3,5-bis[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenyl-1-propanone | [CAS]
61463-04-5 | [Synonyms]
Diuvaretin
1-[2,4-Dihydroxy-3,5-bis[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenyl-1-propanone
1-Propanone, 1-[2,4-dihydroxy-3,5-bis[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenyl- | [Molecular Formula]
C30H28O6 | [MOL File]
61463-04-5.mol | [Molecular Weight]
484.54 |
| Hazard Information | Back Directory | [Uses]
It is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research. | [Definition]
ChEBI: Diuvaretin is a member of the class of dihydrochalcones that is dihydrochalcone substituted by 2-hydroxybenzyl groups at positions 3 and 5, hydroxy groups at positions 2 and 4 and a methoxy group at position 6. Isolated from the roots of Uvaria acuminata and Uvaria chamae, it exhibits cytotoxicity towards human promyelocytic leukemia HL-60 cells. It has a role as a metabolite, an antineoplastic agent and an antimalarial. It is a member of dihydrochalcones, a member of resorcinols and a monomethoxybenzene. | [Biological Activity]
Diuvaretin exhibits cytotoxicity towards human promyelocytic leukemia HL-60 cells. It has a role as a metabolitean antineoplastic agent and an antimalarial. ''Diuvaretin inhibits NF-kB activationhindering inflammation and cancer. It also suppresses tumor cell proliferationinduces apoptosisand diminishes tumor growth and angiogenesis in mouse cancer models. |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|