| Identification | Back Directory | [Name]
4-HYDROXYCINNAMIC ACID (L-PHENYLALANINE METHYL ESTER) AMIDE | [CAS]
615264-52-3 | [Synonyms]
CAY10486
CAY10486,CAY-10486
4-HYDROXYCINNAMIC ACID (L-PHENYLALANINE METHYL ESTER) AMIDE
N-[3-(4-HYDROXYPHENYL)-1-OXO-2-PROPENYL]-L-PHENYLALANINE, METHYL ESTER
L-Phenylalanine, N-[3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-, methyl ester | [Molecular Formula]
C19H19NO4 | [MDL Number]
MFCD08062178 | [MOL File]
615264-52-3.mol | [Molecular Weight]
325.36 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:5): .5 mg/ml; Ethanol: 20 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of approximately 60 μM. It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 μM. | [Uses]
LDL-IN-1 (Compound 1) is an antioxidant, and is active against copper mediated LDL oxidation (IC50 = 52 μM). LDL-IN-1 is also an Acyl-CoA:cholesterol acyltransferase-1 and -2 (ACAT-1/2) inhibitor, with IC50s of 60 μM. LDL-IN-1 can be used for anti-atherosclerotic research[1]. | [storage]
Store at -20°C | [References]
[1] Lee S, et al. Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4677-81. DOI:10.1016/j.bmcl.2004.06.101 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|