| Identification | Back Directory | [Name]
2-Chloro-6-(dimethylamino)pyrazine | [CAS]
61655-72-9 | [Synonyms]
2-Chloro-6-dimethylaminopyrazine
2-dimethylamino-6-chloropyrazine
2-Chloro-6-(dimethylamino)pyrazine
6-chloro-N,N-diMethylpyrazin-2-aMine
6-chloro-N,N-dimethyl-2-Pyrazinamine
6-(N,N-dimethylamino)-2-chloropyrazine
2-Pyrazinamine, 6-chloro-N,N-dimethyl-
6-chloro-N,N-dimethyl-2-pyrazinamine(SALTDATA: FREE) | [Molecular Formula]
C6H8ClN3 | [MDL Number]
MFCD12024889 | [MOL File]
61655-72-9.mol | [Molecular Weight]
157.6 |
| Chemical Properties | Back Directory | [Boiling point ]
248.7±35.0 °C(Predicted) | [density ]
1.252±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
0.97±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
GENERAL STEPS: 2,6-Dichloropyrazine (2.0 g, 13.4 mmol) was dissolved in 13 mL of dimethyl sulfoxide (DMSO). Dimethylamine hydrochloride (1.31 g, 16.08 mmol) and N,N-diisopropylethylamine (DIPEA, 5.2 mL, 30 mmol) were then added sequentially, and the reaction was stirred at room temperature for 24 hours. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate (EtOAc). The organic phase was purified by column chromatography to afford the target compound N-(6-chloro-2-pyrazine)-N,N-dimethylamine (1.82 g, 86% yield).1H-NMR (CDCl3) δ 7.87 (1H, s), 7.77 (1H, s), 3.13 (6H, s). | [References]
[1] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0487 |
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| Company Name: |
SynAsst Chemical.
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| Tel: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
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