| Identification | Back Directory | [Name]
BENZAMIDINE | [CAS]
618-39-3 | [Synonyms]
BENZAMIDINE
phenylamidine
benzylamidine
benziMidaMide
EINECS 210-546-3
Phenylmethanamidine
benzenecarbonamidine
BENZENECARBOXIMIDAMIDE
α-Iminobenzenemethanamine | [EINECS(EC#)]
210-546-3 | [Molecular Formula]
C7H8N2 | [MDL Number]
MFCD00042826 | [MOL File]
618-39-3.mol | [Molecular Weight]
120.15 |
| Chemical Properties | Back Directory | [Melting point ]
65-70 °C
| [Boiling point ]
208.5±23.0 °C(Predicted) | [density ]
1.09±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
powder or crystals | [pka]
11.90±0.40(Predicted) | [color ]
White to Off-White | [BRN ]
606020 |
| Hazard Information | Back Directory | [Uses]
Benzamidine was used in the preparation of heparan sulfate-rich proteoglycan from mouse mammary epithelial cells. It has been used to prevent enzymatic degradation during the purification procedure of bovine factor XII (Hageman factor). | [Definition]
ChEBI: Benzamidine is a carboxamidine that is benzene carrying an amidino group. It has a role as a serine protease inhibitor. It is a member of benzenes and a carboxamidine. It is functionally related to a benzoic acid. It is a conjugate base of a benzamidine(1+). | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 27, p. 1255, 1962 DOI: 10.1021/jo01051a033
Tetrahedron Letters, 31, p. 1969, 1990 DOI: 10.1016/S0040-4039(00)88891-7 | [Biochem/physiol Actions]
Benzamidine is an inhibitor of plasmin and has been used in the radioimmunoassay of glucagon in human plasma. It prevents the destruction of Thyrotropin-releasing hormone (TRH) added to whole blood in vitro before radioimmunoassay of TRH. | [Purification Methods]
It is liberated from its hydrochloride chloride (below) by treatment with 5M NaOH, extracted into diethyl ether, dried (Na2SO4) and sublimed in vacuo.[Beilstein 9 H 280, 9 I 123, 9 II 199, 9 1264, 9 IV 898.] |
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| Company Name: |
Energy Chemical
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| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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