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618094-85-2

618094-85-2 Structure

618094-85-2 Structure
IdentificationBack Directory
[Name]

/
[CAS]

618094-85-2
[Synonyms]

Guan-fu base A hydrochloride
[Molecular Formula]

ClH
[MOL File]

618094-85-2.mol
[Molecular Weight]

36.4609
Chemical PropertiesBack Directory
[InChI]

InChI=1S/ClH/h1H
[InChIKey]

VEXZGXHMUGYJMC-UHFFFAOYSA-N
[SMILES]

[H]Cl
Hazard InformationBack Directory
[Uses]

Guanfu base A hydrochloride is an antiarrhythmic alkaloid with the ability to inhibit CYP2D6 enzyme activity. Guanfu base A hydrochloride can be used to inhibit arrhythmia-related diseases. Guanfu base A hydrochloride exhibits inhibitory effects on CYP2D6 in different species of organisms, including humans, monkeys, and dogs. The biological activity of Guanfu base A hydrochloride makes it have potential clinical application value[1].
[References]

[1] Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24. DOI:10.1124/dmd.114.060905
[2] Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms DOI:10.1124/dmd.114.060905
[3] Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. DOI:10.1097/FJC.0b013e318236e380
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