| Identification | Back Directory | [Name]
SB-743291 | [CAS]
618430-39-0 | [Synonyms]
SB921
SB-921
GSK-921
SB-743291
GSK-743921
SB-743921 free base
SB 743921 free base,SB743921 free base
N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxochromen-2-yl)-2-methylpropyl]-4-methylbenzamide
N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl]-4-methylbenzamide
BenzaMide, N-(3-aMinopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylMethyl)-4H-1-benzopyran-2-yl]-2-Methylpropyl]-4-Methyl- | [Molecular Formula]
C31H33ClN2O3 | [MDL Number]
MFCD22628880 | [MOL File]
618430-39-0.mol | [Molecular Weight]
517.06 |
| Hazard Information | Back Directory | [Uses]
SB-743921 free base is a potent selective inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM. SB-743921 free base can induce mitotic arrest, block cell cycle progression, induce apoptosis, and can be used in the research of myeloma, leukemia and other diseases[1][2]. | [in vivo]
SB-743921 has good oral bioavailability and pharmacokinetics and induces complete tumor regression in nude mice bearing lung cancer patient xenografts[3]. | [References]
[1] Jeffrey R. Jackson, et al. A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer. First AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development, Sep 12-15, 2006.
[2] Yin Y, et al. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Leuk Lymphoma. 2015 Jun;56(6):1813-20. DOI:10.3109/10428194.2014.956319
[3] Good JA, et al. Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. J Med Chem. 2013 Mar 14;56(5):1878-93. DOI:10.1021/jm3014597 |
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| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
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