| Identification | Back Directory | [Name]
Insulin-like growth factor | [CAS]
61912-98-9 | [Synonyms]
IGF
IGF-I
IGFIA
Somatamedin C
IGF-I from rat
LONG(TM) R3 IGF-1
HUMAN LONG R3IGF-I
Insulin-like growth factor
INSULIN-LIKE GROWTH FACTOR-I HUMAN | [MDL Number]
MFCD00147463 |
| Hazard Information | Back Directory | [Uses]
Insulin-like Growth Factor-I human has been used:
- in modified Dulbecco minimal essential medium for in vitro culture of testicular cells
- in culture media, to study its effect on steroidogenesis during testicular development
- in culture media for in vitro assay of splenic pro-erythroid cell growth and differentiation
| [Biological Activity]
IGF-I also known as somatomedin Cis secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. In the developing embryo IGF-I is expressed primarily by mesenchymal-derived cells. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differentlydepending on the specific tissues. For examplegonadotropins and sex steroids regulate IGF-I expression within the reproductive systemwhile parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblastsosteoblastssmooth muscle cellsfetal brain cellsneuroglial cellsand erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell mig |
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