61939-05-7

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61939-05-7 Structure

Identification	Back Directory
[Name] DESOXYPEGANINE HYDROCHLORIDE
[CAS] 61939-05-7
[Synonyms] DEOXYPEGANINE HCL Deoxyvasicine HCl DESOXYPEGANINE HCL pegenehydrochloride deoxypeganinehydrochloride deoxyvasicinehydrochloride deoxy-vasicinhydrochloride DESOXYPEGANINE HYDROCHLORIDE Vasicine, deoxy-, hydrochloride 1H,2H,3H,9H-pyrrolo[2,1-b]quinazoline hydrochloride 1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazoline hydrochloride 1,2,3,8-Tetrahydropyrroll[2,1-b]-chynazolina chlorohydrate 1-b)quinazoline,1,2,3,9-tetrahydro-pyrrolo(monohydrochloride Pyrrolo(2,1-B)quinazoline, 1,2,3,9-tetrahydro-, monohydrochloride
[Molecular Formula] C11H13ClN2
[MDL Number] MFCD00155365
[MOL File] 61939-05-7.mol
[Molecular Weight] 208.69

Chemical Properties	Back Directory
[Melting point ] 260 °C

[Uses]

Desoxypeganine Hydrochloride is a naturally occurring alkaloid that is a cholinesterase inhibitor.

[in vivo]

Desoxypeganine hydrochloride (10-30 mg/kg, gavage, once daily for 16 days) reduced ethanol intake and ethanol preference dose-dependently^[1].

Animal Model:	Female Alko alcohol (AA) rats (Thirty eight adult)^[1]
Dosage:	10, 20, 30 mg/kg
Administration:	Gavage, once daily in a volume of 10 ml/kg at 6:00 pm, for 16 days
Result:	Abolished ethanol preference.

[IC 50]

BChE: 2 μM (IC₅₀); AChE: 17 μM (IC₅₀); MAO-A: 2 μM (IC₅₀)

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