| Identification | Back Directory | [Name]
CUCURBITACIN B | [CAS]
6199-67-3 | [Synonyms]
Cuc B
AMARINE
HSDB 3476
DATISCACIN
NSC-144154
heMsecin A
Cucurbitacin
cucurbitacineb
CUCURBITACIN B
BCucurbitacin B
CUCURBITACIN B(P)
CUCURBITACIN B(RG)
Cucurbitacin B ,97%
Cucurbitacin B, >99%
Cucurbitacin B hydrate
CUCURBITACIN B USP/EP/BP
1,2-DIHYDRO-ALPHA-ELATERIN
Dihydrocucurbitacin F-25-acetate
Cucurbitacin B, froM CucuMis Melo
Cucurbitacin B, 98%, from Cucumis melo
(2beta,9beta,10alpha,16alpha,23e)-thyl
Cucurbitacin B, 98%, from Cucumis melo L.
CAS?6199-67-3?Combretastatin A4 (Z) -Combretastatin A4 CAS 117048-59-6
(23E)-25-(Acetyloxy)-2β,16α,20-trihydroxycucurbita-5,23-diene-3,11,22-trione
19-nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione,2-beta,16-alpha,20,25
19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet
19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me
25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-tr
(9β,10α,23E)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione
(2β,9β,10α,16α,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-Norlanosta-5,23-diene-3,11,22-trione
19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2β,9β,10α,16α,23E)- | [Molecular Formula]
C32H46O8 | [MDL Number]
MFCD07778083 | [MOL File]
6199-67-3.mol | [Molecular Weight]
558.7 |
| Chemical Properties | Back Directory | [Melting point ]
184-186° | [alpha ]
D25 +88° (c = 1.55 in ethanol) | [Boiling point ]
546.74°C (rough estimate) | [density ]
1.0953 (rough estimate) | [refractive index ]
1.4900 (estimate) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
12.60±0.29(Predicted) | [color ]
white to beige | [λmax]
290nm(EtOH)(lit.) | [Merck ]
14,2614 | [Stability:]
Hygroscopic | [Cosmetics Ingredients Functions]
SKIN CONDITIONING | [InChIKey]
IXQKXEUSCPEQRD-ALLWXVAWSA-N | [SMILES]
CC1(C)C([C@@H](O)C[C@]2([H])C1=CC[C@]([C@@](C[C@@H](O)[C@]3([H])[C@@](C)(O)C(/C=C/C(C)(C)OC(C)=O)=O)(C)[C@]3(C)C4)([H])[C@@]2(C)C4=O)=O |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45-24/25 | [RIDADR ]
UN 2811 6.1 / PGI | [WGK Germany ]
3 | [RTECS ]
RC6190000 | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29153900 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 2 Oral | [Hazardous Substances Data]
6199-67-3(Hazardous Substances Data) | [Toxicity]
LD10 orally in mice: 5 mg/kg (LeMen) |
| Hazard Information | Back Directory | [Description]
Cucurbitacin B is a tetracyclic triterpenoid that has been shown to have a strong antitumor activity. | [Chemical Properties]
White solid | [Uses]
Cucurbitacin B hydrate has been used:
- as a signal transducer and activator of transcription 3 (stat3) inhibitor to determine its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs).
- as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydoxyecdysone (20E) signaling in butterflies.
- to determine its effect on the cell viability of pancreatic cancer cell lines.
| [Definition]
ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated. | [Biochem/physiol Actions]
Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I. |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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