| Identification | Back Directory | [Name]
Benzotriazol-1-ylmethyl-(4-chloro-phenyl)-amine | [CAS]
62001-32-5 | [Synonyms]
GI-568769
Benzotriazol-1-ylmethyl-(4-chloro-phenyl)-amine
1H-Benzotriazole-1-methanamine, N-(4-chlorophenyl)- | [Molecular Formula]
C13H11ClN4 | [MDL Number]
MFCD00451363 | [MOL File]
62001-32-5.mol | [Molecular Weight]
258.71 |
| Chemical Properties | Back Directory | [Melting point ]
164 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
497.6±25.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [pka]
1.98±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
RSK2-IN-4 (Compound 10) is a RSK2 inhibitor, with an inhibition rate of 13.73% on RSK2 activity at 10 μM. RSK2-IN-4 binds to the ATP-binding site of RSK2 in the NTKD (N-terminal kinase domain), with the electron-donating group at the 4-position of the phenyl ring being the key determinant for its inhibitory activity [1]. | [References]
[1] Yuan J, et al. Triazole and benzotriazole derivatives as novel inhibitors for p90 ribosomal S6 protein kinase 2: synthesis, molecular docking and SAR analysis[J]. Chinese Journal of Chemistry, 2013, 31(9): 1192-1198. |
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Merck KGaA
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21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
A2B Chem LLC
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| Tel: |
010 |
| Website: |
www.a2bchem.com |
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