62068-78-4

40381-90-6

62068-78-4

General procedure for the synthesis of 2,6-dichloronicotinamide from 2,6-dichloronicotinonitrile: To 2,6-dichloronicotinonitrile (1.73 g, 10 mmol) was added concentrated sulfuric acid (10 mL) and water (2 mL). The reaction mixture was heated to 90 °C and stirred continuously for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently slowly poured into ice water. The pH of the mixture was adjusted with ammonia to 8. The precipitate precipitated was collected by filtration, washed with cold water (20 mL) and finally dried under vacuum to give 2,6-dichloronicotinamide as a brown solid (1.4 g, 73% yield). Mass spectrum (ESI): m/z = 191.1 [M + H]+.