| Identification | Back Directory | [Name]
3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE | [CAS]
622387-85-3 | [Synonyms]
OXSI 2
Syk Inhibitor
3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-2-OXO-1H-INDOLE-5-SULFONAMIDE
3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide
1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo- | [Molecular Formula]
C18H15N3O3S | [MDL Number]
MFCD07776820 | [MOL File]
622387-85-3.mol | [Molecular Weight]
353.39 |
| Hazard Information | Back Directory | [Description]
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 14 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM). At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change. | [Uses]
OXSI 2 is a Syk selective inhibitor. | [storage]
Store at -20°C |
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BOC Sciences
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https://www.bocsci.com |
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Creative Enzymes
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1-516-855-7709 |
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www.creative-enzymes.com |
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