| Identification | Back Directory | [Name]
Orotirelin | [CAS]
62305-86-6 | [Synonyms]
CG 3509
Orotirelin
Orotireline
N-[(1,2,3,6-Tetrahydro-2,6-dioxopyrimidin-4-yl)carbonyl]-L-His-L-Pro-NH2
L-Prolinamide, 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl- | [Molecular Formula]
C16H19N7O5 | [MDL Number]
MFCD00867367 | [MOL File]
62305-86-6.mol | [Molecular Weight]
389.37 |
| Hazard Information | Back Directory | [Uses]
Orotirelin is an analogue of Thyrotropin-releasing hormone (T413510) with possible therapeutic application in sleep disorders. | [in vivo]
In the pentobarbitone anaesthetized rats, Bilateral injection of Orotirelin (0.1-1.0 μg) into the nucleus accumbens reduced the Pentobarbitone-induced sleeping time[1]. | Animal Model: | Male Sprague-Dawley rats (270-290 g) anaesthetized with Sodium Pentobarbitone (60mg/kg, i.p.)[1] | | Dosage: | 0.1-1.0 μg (0.5 μL each side) | | Administration: | Intracerebral injection; once | | Result: | Reversed the Pentobarbitone-induced sleeping time. |
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