623155-53-3

101207-48-1

623155-53-3

General procedure for the synthesis of 4-methyl-3-nitrobenzylamine using the compound (CAS:101207-48-1) as starting material: the above solid material (0.75 g) was suspended in ethanol (EtOH, 25 mL) followed by the addition of hydrazine (0.39 mL). The reaction mixture was heated to 60°C and maintained at this temperature for 8 hours and then cooled to room temperature. Methanol (MeOH, 25 mL) was added to the reaction system and stirred rapidly to promote solid fragmentation. The product was separated by filtration and washed with methanol (2 x 25 mL) to give the final 4-methyl-3-nitrobenzylamine (0.38 g, 90% yield).