| Identification | Back Directory | [Name]
(3'R,6S,9R)-5,6,7,8,9,10-Hexahydro-5'-(2,2,2-trifluoroethyl)-2-[(1E)-3-[4-(trifluoromethyl)-1-piperidinyl]-1-propen-1-yl]spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazolidine] 1',1'-dioxide | [CAS]
623165-93-5 | [Synonyms]
CS-771
MRK 003
(3'R,6S,9R)-5,6,7,8,9,10-Hexahydro-5'-(2,2,2-trifluoroethyl)-2-[(1E)-3-[4-(trifluoromethyl)-1-
(3'R,6S,9R)-5,6,7,8,9,10-Hexahydro-5'-(2,2,2-trifluoroethyl)-2-[(1E)-3-[4-(trifluoromethyl)-1-piperidinyl]-1-propen-1-yl]spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazolidine] 1',1'-dioxide
Spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazolidine], 5,6,7,8,9,10-hexahydro-5'-(2,2,2-trifluoroethyl)-2-[(1E)-3-[4-(trifluoromethyl)-1-piperidinyl]-1-propen-1-yl]-, 1',1'-dioxide, (3'R,6S,9R)- | [Molecular Formula]
C25H31F6N3O2S | [MDL Number]
MFCD23136012 | [MOL File]
623165-93-5.mol | [Molecular Weight]
551.59 |
| Hazard Information | Back Directory | [Uses]
MRK 003 is a potent, selective and orally active γ-secretase inhibitor. MRK 003 reduce brain Aβ production in vivo. MRK 003 induces caspase-dependent apoptosis and inhibits tumor cell proliferation in vivo and in vitro[1][2][3]. | [References]
[1] Lewis HD, et al. Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling. Chem Biol. 2007;14(2):209-219. DOI:10.1016/j.chembiol.2006.12.010
[2] Sparey T, et al. Cyclic sulfamide gamma-secretase inhibitors. Bioorg Med Chem Lett. 2005;15(19):4212-4216. DOI:10.1016/j.bmcl.2005.06.084
[3] Mizuma M, et al. The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models. Mol Cancer Ther. 2012;11(9):1999-2009. DOI:10.1158/1535-7163.MCT-12-0017 |
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China Langchem Inc.
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0086-21-58956006 |
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www.chemicalbook.com/ShowSupplierProductsList19141/0.htm |
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SPIRO PHARMA
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www.spiropharma.com.cn |
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Cckinase, Inc.
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+1 (732)236-3202 |
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www.cckinase.com |
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