| Identification | Back Directory | [Name]
tiglyl-coenzyme A | [CAS]
6247-62-7 | [Synonyms]
tiglyl-coenzyme A
Coenzyme A, S-[(2E)-2-methyl-2-butenoate] | [Molecular Formula]
C26H42N7O17P3S | [MOL File]
6247-62-7.mol | [Molecular Weight]
849.64 |
| Chemical Properties | Back Directory | [density ]
1.79±0.1 g/cm3(Predicted) | [pka]
1.16±0.50(Predicted) | [InChIKey]
PMWATMXOQQZNBX-NOXORWHSNA-N | [SMILES]
O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)/C(/C)=C/C)O[C@H]1N1C=NC2C(=NC=NC1=2)N)OP(O)(O)=O |&1:1,2,3,18,38,r| |
| Hazard Information | Back Directory | [Uses]
Tigloyl-CoA (Tiglyl-coenzyme A) is an intermediate product of isoleucine metabolism. Tigloyl-CoA is an inhibitor of N-acetylglutamate synthetase[1]. | [Definition]
ChEBI: 2-methylcrotonoyl-CoA is a 2-enoyl-CoA and a monounsaturated fatty acyl-CoA. It is functionally related to a but-2-enoyl-CoA and a tiglic acid. It is a conjugate acid of a 2-methylcrotonoyl-CoA(4-). | [References]
[1] Coude FX, et al. Inhibition by propionyl-coenzyme A of N-acetylglutamate synthetase in rat liver mitochondria. A possible explanation for hyperammonemia in propionic and methylmalonic acidemia. J Clin Invest. 1979 Dec;64(6):1544-51. DOI:10.1172/JCI109614 |
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