| Identification | Back Directory | [Name]
3-[4-(2-Methoxyethyl)phenoxy]- | [CAS]
62572-90-1 | [Synonyms]
Metoprolol-4
Desloratadine EP Impurity
Metoprolol tartrate impurity D
3-[4-(2-Methoxyethyl)phenoxy]-
Metoprolol Impurity-D(70% pure)
Metoprolol Succinate Impurity D
Metoprolol tartrate EP impurity D
Metoprolol EP Tartrate IMpurity-D
Metoprolol Succinate EP Impurity D
(2RS)-3-[4-(2-Methoxyethyl)phenoxy]
3-[4-(2-Methoxyethyl)phenoxy]-1,2-propanediol
Metoprolol Impurity 4(Metoprolol EP Impurity D)
1,2-Propanediol, 3-[4-(2-methoxyethyl)phenoxy]-
(2RS)-3-[4-(2-Methoxyethyl)phenoxy]propane-1,2-diol
Imp. D (EP):(2RS)-3-[4-(2-Methoxyethyl)phenoxy]propane-1,2-diol
Metoprolol impurity 3/Metoprolol EP Impurity D/3-[4-(2-Methoxyethyl)phenoxy]-1,2-propanediol | [Molecular Formula]
C12H18O4 | [MDL Number]
MFCD18382386 | [MOL File]
62572-90-1.mol | [Molecular Weight]
226.269 |
| Questions And Answer | Back Directory | [Synthesis]
g of compound III (0.032 mol), 130 mL of 1N dilute hydrochloric acid (0.13 mol), and 9 g of sodium nitrite (0.13 mol) were added to a 250 mL round-bottom flask. The mixture was stirred at 60 °C for 3 h. The reaction progress was monitored by TLC (electrolyte:ethyl acetate:methanol:triethylamine = 3:1:2 drops). The reaction was stopped when the reaction was complete. 7 g of sodium bicarbonate was added to the reaction mixture while stirring. A large number of bubbles were generated. The mixture was extracted with 100 mL × 2 ethyl acetate. The combined organic phases were washed with 100 mL × 2 saturated brine and dried over 14 g of anhydrous sodium sulfate. The mixture was rotary evaporated to obtain 7 g of an orange-yellow oily liquid, which was eluted with petroleum ether:ethyl acetate = 1:1. 5.2 g of white solid was obtained, with a yield of 68.27%.  |
| Chemical Properties | Back Directory | [Boiling point ]
382.7±32.0 °C(Predicted) | [density ]
1.145±0.06 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.53±0.20(Predicted) | [color ]
White to Off-White | [Major Application]
pharmaceutical small molecule | [InChI]
1S/C12H18O4/c1-15-7-6-10-2-4-12(5-3-10)16-9-11(14)8-13/h2-5,11,13-14H,6-9H2,1H3 | [InChIKey]
MELFVOGWPJFQBB-UHFFFAOYSA-N | [SMILES]
OCC(O)COC1=CC=C(CCOC)C=C1 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
TOSUN PHARM
|
| Telephone: |
020-66392521-118 18922260391 |
| Website: |
www.toref.cn/ |
|