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62615-24-1

62615-24-1 Structure

62615-24-1 Structure
IdentificationBack Directory
[Name]

2-Iodo-4-acetylphenol
[CAS]

62615-24-1
[Synonyms]

2-Iodo-4-acetylphenol
4-Acetyl-2-iodophenol
3'-Iodo-4'-hydroxyacetophenone
4'-Hydroxy-3'-iodoacetophenone
4'-Hydroxy-3'-iodoacetophenone 97%
1-(4-Hydroxy-3-iodo-phenyl)-ethanone
Ethanone, 1-(4-hydroxy-3-iodophenyl)-
[Molecular Formula]

C8H7IO2
[MDL Number]

MFCD06200221
[MOL File]

62615-24-1.mol
[Molecular Weight]

262.04
Chemical PropertiesBack Directory
[Melting point ]

155-160°C
[form ]

powder
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22-41
[Safety Statements ]

26-39
[WGK Germany ]

1
Hazard InformationBack Directory
[Uses]

Reactant for:
  • Preparation of cyclopentene fused benzofurans and indoles via Pd-catalyzed tandem ring opening-ring closing reaction with diazabicyclic alkenes
  • Highly regioselective synthesis of spirocyclic compounds by a palladium-catalyzed intermolecular tandem reaction
  • Regioselective synthesis of indene derivatives via Pd/C-catalyzed cyclization reaction in air
  • Preparation of carbazoles via cross-coupling with silylaryl triflates followed by palladium-catalyzed cyclization
  • Stereoselective preparation of heteropolycyclic compounds via palladium-catalyzed stereoselective heteroannulation of with cyclic alkenes
  • Preparation of disubstituted coumarins via palladium-catalyzed carbonylative annulation of internal alkynes
  • Preparation of arylalkynes, benzofurans and indoles via Sonogashira coupling and cyclization on alumina
[Preparation]

Preparation by reaction of iodine and potassium iodide on 4-hydroxyacetophenone in aqueous ammonium hydroxide at r.t. (54–57%).
[Synthesis Reference(s)]

Journal of Medicinal Chemistry, 23, p. 738, 1980 DOI: 10.1021/jm00181a008
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