ChemicalBook--->CAS DataBase List--->626220-76-6

626220-76-6

626220-76-6 Structure

626220-76-6 Structure
IdentificationBack Directory
[Name]

(R)-1-methoxypropan-2-amine hydrochloride
[CAS]

626220-76-6
[Synonyms]

CAS:626220-76-6
(R)-1-Methoxypropan-2-amine, HCl
(R)-(-)-1-Methoxy-2-PropylaMine HCl
(R)-1-methoxypropan-2-amine hydrochloride
(2R)-1-Methoxypropan-2-amine hydrochloride
(R)-(-)-1-Methoxy-2-propylaMine hydrochloride
2-PropanaMine, 1-Methoxy-, hydrochloride, (2R)-
((R)-2-Methoxy-1-methylethyl)amine hydrochloride
[Molecular Formula]

C4H12ClNO
[MDL Number]

MFCD12405301
[MOL File]

626220-76-6.mol
[Molecular Weight]

126
Chemical PropertiesBack Directory
[storage temp. ]

under inert gas (nitrogen or Argon) at 2-8°C
[Appearance]

White to off-white Solid
[Optical Rotation]

Consistent with structure
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H319-H315-H335
[Precautionary statements ]

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Spectrum DetailBack Directory
[Spectrum Detail]

(R)-1-methoxypropan-2-amine hydrochloride(626220-76-6)1HNMR
Hazard InformationBack Directory
[Synthesis]

Carbamic acid, N-[(1R)-2-methoxy-1-methylethyl]-, 1,1-dimethylethyl ester

955399-15-2

(R)-1-methoxypropan-2-amine hydrochloride

626220-76-6

Step 3: (S)-Boc-2-methoxy-1-methylethylamine (955399-15-2) was dissolved in methanol (40 mL) and 3M hydrochloric acid solution (10 mL) was slowly added. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was co-evaporated with ethanol (20 mL) to afford (S)-2-methoxy-1-methylethylamine hydrochloride as a light brown oil (1.42 g, 100% yield). Mass spectrometry analysis showed the molecular ion peak (M+H)+ m/z = 90.

[References]

[1] Patent: US2008/4442, 2008, A1. Location in patent: Page/Page column 197
[2] Patent: WO2008/55840, 2008, A1. Location in patent: Page/Page column 58
[3] Patent: US2009/163502, 2009, A1. Location in patent: Page/Page column 40
[4] Patent: US2009/163499, 2009, A1. Location in patent: Page/Page column 28
[5] Patent: US2010/324056, 2010, A1. Location in patent: Page/Page column 30
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