| Identification | Back Directory | [Name]
GSK-3β Inhibitor XI | [CAS]
626604-39-5 | [Synonyms]
GSK3β Inhibitor XI
GSK 3B Inhibitor XI
GSK-3β Inhibitor XI
4-[1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-(pyrazin-2-yl)pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-(2-pyrazinyl)- | [Molecular Formula]
C18H15N5O3 | [MDL Number]
MFCD09037534 | [MOL File]
626604-39-5.mol | [Molecular Weight]
349.34 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 5 mg/ml | [form ]
A solid | [color ]
orange-red | [InChI]
1S/C18H15N5O3/c24-8-2-7-23-10-12(11-3-1-4-21-16(11)23)14-15(18(26)22-17(14)25)13-9-19-5-6-20-13/h1,3-6,9-10,24H,2,7-8H2,(H,22,25,26) | [InChIKey]
ZDEJZKULWCZIHL-UHFFFAOYSA-N | [SMILES]
N1C(=O)C(=C(C1=O)c3c4c([n](c3)CCCO)nccc4)c2nccnc2 |
| Hazard Information | Back Directory | [Description]
ZUN04395, also known as GSK3β inhibitor XI, is a potent inhibitor of glycogen synthase kinase 3β. | [Uses]
GSK-3b Inhibitor XI (Compound 33) is a potent and selective GSK3β inhibitor, with a Ki value of 25 nM. GSK-3b Inhibitor XI increases glycogen synthase (GS) activity. GSK-3b Inhibitor XI can be used for research on type 2 diabetes and Alzheimer’s disease[1]. | [IC 50]
GSK-3β | [References]
[1] O'Neill, et al. Design, synthesis, and biological evaluation of novel 7-azaindolylheteroaryl-maleimides as potent and selective glycogen synthase kinase-3β (GSK-3β) inhibitors. Bioorg. Med. Chem. 12(12), 3167-3185 (2004). |
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