| Identification | Back Directory | [Name]
4-Piperidinol, 1-[[1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-4-piperidinyl]methyl]- | [CAS]
627052-25-9 | [Synonyms]
SQ609
SQ609,SQ-609
4-Piperidinol, 1-[[1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-4-piperidinyl]methyl]- | [Molecular Formula]
C22H38N2O | [MDL Number]
MFCD28502121 | [MOL File]
627052-25-9.mol | [Molecular Weight]
346.55 |
| Chemical Properties | Back Directory | [Boiling point ]
479.0±20.0 °C(Predicted) | [density ]
1.105±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 6.67 mg/mL (19.25 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
14.87±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity [1]. | [in vivo]
SQ609 (10 mg/kg; intravenous injection) completely prevents weight loss in the Mtb-infected animals and prolongs the therapeutic effect following drug withdrawal for another 10-15 days[1]. | Animal Model: | TB susceptible mice (C3H/He)[1] | | Dosage: | 10 mg/kg | | Administration: | I.v. | | Result: | Prevented weight loss in the Mtb-infected animals and prolonged the therapeutic effect following drug withdrawal for another 10-15 days.
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| [References]
[1] Bogatcheva E, et al. Identification of SQ609 as a lead compound from a library of dipiperidines. Bioorg Med Chem Lett. 2011;21(18):5353-5357. DOI:10.1016/j.bmcl.2011.07.015 |
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| Company Name: |
Elucigen bio
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| Tel: |
13501719342; 13501719342 |
| Website: |
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