| Identification | Back Directory | [Name]
(3beta,20beta)-3-acetoxy-11-oxoolean-12-en-29-oic acid | [CAS]
6277-14-1 | [Synonyms]
Acetoxolone
Einecs 228-475-1
Acetylglycyrrhetic acid
acetylglycyrrhetinic acid
Glycyrrhetic acid acetate
29728-34-5 (Aluminum salt)
3-Acetyl-18-beta-glycyrrhetinic acid
3-O-Acetyl-18beta-glycyrrhetinic acid
3β-(Acetyloxy)-11-oxoolean-12-en-30-oic acid
(20S)-3β-(Acetyloxy)-11-oxoolean-12-en-29-oic acid
(3beta,20beta)-3-acetoxy-11-oxoolean-12-en-29-oic acid
Olean-12-en-29-oicacid, 3-(acetyloxy)-11-oxo-, (3b,20b)-
Olean-12-en-29-oic acid, 3-(acetyloxy)-11-oxo-, (3β,20β)-
(3-beta,20-beta)-3-(Acetyloxy)-11-oxo-olean-12-en-29-oic acid
(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-acetyloxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylicaci | [EINECS(EC#)]
228-475-1 | [Molecular Formula]
C32H48O5 | [MOL File]
6277-14-1.mol | [Molecular Weight]
512.72 |
| Chemical Properties | Back Directory | [Melting point ]
322-325° | [alpha ]
D20 +141° | [Boiling point ]
597.0±50.0 °C(Predicted) | [density ]
1.14±0.1 g/cm3(Predicted) | [vapor pressure ]
0-0Pa at 20-30℃ | [pka]
4.71±0.70(Predicted) | [LogP]
4.77 at 35℃ and pH2.25 |
| Hazard Information | Back Directory | [Originator]
Oriens ,Inverni Beffa ,Italy ,1981 | [Definition]
ChEBI: Acetoxolone is a triterpenoid. | [Manufacturing Process]
The salts of 3-acetyl-18β-glycyrrhetinic acid can be prepared by reaction
between 3-acetyl-18β-glycyrrhetinic acid and an aluminum alcoholate.
Preferably lower alcoholates are used, i.e., alcoholates in which the alkoxy
group or groups have from one to four carbon atoms. The salification reaction
may be carried out at room temperature or at an elevated temperature in
conventional fashion, preferably in the presence of organic solvents. As
organic solvents may be used alcohols, ethers, ketones, chlorinated solvents
(methylene chloride, chloroform) ethyl acetate, etc. | [Therapeutic Function]
Antiulcer |
|
|