| Identification | Back Directory | [Name]
5,6ALPHA-DIHYDRO PGI2 | [CAS]
62777-90-6 | [Synonyms]
6α-Prostaglandin I1
5,6ALPHA-DIHYDRO PGI2
6ALPHA-PROSTAGLANDIN I1
RJADQDXZYFCVHV-WDONHGPHSA-N
6R,9ALPHA-EPOXY-11ALPHA,15S-DIHYDROXY-PROST-13E-EN-1-OIC ACID
(6R,13E,15S)-6,9α-Epoxy-11α,15-dihydroxyprost-13-en-1-oic acid
Prost-13-en-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (6R,9α,11α,13E,15S)- (9CI) | [Molecular Formula]
C20H34O5 | [MDL Number]
MFCD00797658 | [MOL File]
62777-90-6.mol | [Molecular Weight]
354.48 |
| Chemical Properties | Back Directory | [Boiling point ]
528.202±35.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.147±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: >10 (from (6b-PGI1); DMSO: >5 (from (6b-PGI1); Ethanol: >20 mg/ml (from (6b-PGI1); PBS pH 7.2: >80 μg (from (6b-PGI1) | [form ]
A crystalline solid | [pka]
4.748±0.10(predicted) |
| Hazard Information | Back Directory | [Description]
6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response.1 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).2 | [Uses]
6α-Prostaglandin I1 (6α-PGI1) is an analogue of prostacycline I2 (PGI2) and is resistant to hydrolysis in aqueous solution[1]. | [Definition]
ChEBI: 6alpha-Prostaglandin I1 is a prostaglandins I. | [storage]
Store at -20°C | [References]
1. Patrono, C., Rotella, C.M., Toccafondi, R.S., et al. Prostacyclin stimulates the adenylate cyclase system of human thyroid tissue Prostaglandins 22(1),105-115(1981).
2. Whittle, B.J.R., and Moncada, S. Prostacyclin and its analogues for the therapy of thromboembolic disorders Adv. Exp. Med. Biol. 164,193-209(1984). |
|
|