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7-Methyl-diguanosine triphosphate (m7Gp3G) is a cap analog that can incorporated into mRNA. 7-Methyl-diguanosine triphosphate is involved in translation and mRNA degradation in mammalian cells[1]. | [Definition]
ChEBI: 7-methyl-guanosine-5'-triphosphate-5'-guanosine is a guanosine 5'-phosphate that is 7-methyl-GTP in which the hydroxy group of the terminal phosphate is substituted by a guanosinyl group. It is a cap analog that can be incorporated into mRNA. It is a guanosine 5'-phosphate and a purine ribonucleoside 5'-triphosphate. It is functionally related to a 7-methyl-GTP. It is a conjugate acid of a (N(7)-methyl 5'-triphospho-guanosine)-guanosine(2-). | [References]
[1] Ewa Grudzien, et al. Differential inhibition of mRNA degradation pathways by novel cap analogs. J Biol Chem. 2006 Jan 27;281(4):1857-67. DOI:10.1074/jbc.M509121200 |
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