| Identification | Back Directory | [Name]
N,N-Bis(2-methyl-6-methoxy-4-quinaldyl)-1,9-diamino- nonane Dihydrochloride Hydrate | [CAS]
6286-09-5 | [Synonyms]
NSC10010
NSC-10010
NSC 10010
NSC#10010
NSC#-10010
NSC# 10010
N,N-Bis(2-methyl-6-methoxy-4-quinaldyl)-1,9-diamino- nonane Dihydrochloride Hydrate | [Molecular Formula]
C31H41ClN4O2 | [MOL File]
6286-09-5.mol | [Molecular Weight]
537.15 |
| Hazard Information | Back Directory | [Description]
NSC10010 is a potent growth inhibitor for gammaherpesvirus-associated B-lymphomas that acts through activation of both the NF-κB and c-Myc-mediated signaling pathways. | [Uses]
NSC10010 hydrochloride inhibits gammaherpesvirus associated B-lymphomas growth through activation of NF-kB and c-Myc-mediated signaling pathways. NSC10010 hydrochloride induces necrotic cell death in gammaherpesvirus infected B-cells. NSC10010 hydrochloride is also an inhibitor of Mtb ClpC1 ATPase[1][2]. | [References]
[1] Dzeng RK, et al. Small molecule growth inhibitors of human oncogenic gammaherpesvirus infected B-cells. Mol Oncol. 2015 Feb;9(2):365-76. DOI:10.1016/j.molonc.2014.09.006
[2] Amritansh Bhanot, et al. Discovery of small molecule inhibitors of Mycobacterium tuberculosis ClpC1: SAR studies and antimycobacterial evaluation. Results in Chemistry. Volume 5, January 2023, 100904. |
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