| Identification | Back Directory | [Name]
Leo 271 f | [CAS]
62899-40-5 | [Synonyms]
Leo 271 f
Estromustine
Bis(2-chloroethyl)carbamic acid 17-oxoestra-1,3,5(10)-trien-3-yl ester
Estra-1,3,5(10)-trien-17-one, 3-[[[bis(2-chloroethyl)amino]carbonyl]oxy]-
(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl bis(2-chloroethyl)carbamate | [Molecular Formula]
C23H29Cl2NO3 | [MDL Number]
MFCD30478704 | [MOL File]
62899-40-5.mol | [Molecular Weight]
438.39 |
| Hazard Information | Back Directory | [Uses]
Estromustine (EoM) is the active metabolite of Estramustine phosphate (HY-13627A). Estromustine binds to mutant androgen receptor (m-AR) with EC50 of 2.6 μM in LNCaP, exhibits cytotoxicity in human prostate cells LNCaP with IC50 of 9.73 μM[1]. | [References]
[1] Wang LG, et al., Androgen antagonistic effect of estramustine phosphate (EMP) metabolites on wild-type and mutated androgen receptor. Biochem Pharmacol. 1998 May 1;55(9):1427-33. DOI:10.1016/s0006-2952(97)00657-6 |
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