| Identification | Back Directory | [Name]
(6R,S)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE | [CAS]
62989-33-7 | [Synonyms]
R-THBP
sapropterin
Dapropterin
(6R,S)-BH4 2HCL
(6R)-Tetrahydrobiopterin
6R-Tetrahydro-L-biopterin
(6R)-5,6,7,8-Tetrahydrobiopterin
Tetrahydro-L-Biopterin free base
6b-5,6,7,8-Tetrahydro-L-biopterin
(6R)-L-erythro-Tetrahydrobiopterin
(6R)-L-erythro-5,6,7,8-Tetrahydrobiopterin
(6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE
(6R,S)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE
2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-4(1H)-Pteridinone
4(1H)-PTERIDINONE,2-AMINO-6-[(1R,2S)-1,2-DIHYDROXYPROPYL]-5,6,7,8-TETRAHYDRO
4(1H)-PTERIDINONE, 2-AMINO-6-[(1R,2S)-1,2-DIHYDROXYPROPYL]-5,6,7,8-TETRAHYDRO-, (6R)-
4(1H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, (6R)-(9CI)
4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-, [6R-[6R*(1R*,2S*)]]-
[6R-[6R^<*>^(1R^<*>^，2S^<*>^)]]-2-Amino-6-(1，2-dihydroxypropyl)-5，6，7，8-tetrahydro-4(1H)-ptefidinone | [EINECS(EC#)]
636-312-4 | [Molecular Formula]
C9H17Cl2N5O3 | [MDL Number]
MFCD00069326 | [MOL File]
62989-33-7.mol | [Molecular Weight]
314.17 |
| Hazard Information | Back Directory | [Chemical Properties]
Pk' 5.05. UV absorption maximum (0.1 mol/L hydrochloric acid): 265 nm (ε 14000). Sapropterin dihydrochloride: C9H15N5O3·2HCl. [69056-38-8]. White crystals or crystalline powder, odorless, slightly sour. Very soluble in water, slightly insoluble in methanol, very insoluble in ethanol, and practically insoluble in ether. Melting point 245-246°C (decomposition). [α]D25 -6.81. (C = 0.665, 0.1 mol/L hydrochloric acid). UV absorption maximum (2 mol/L hydrochloric acid): 264 nm (ε 16770). | [Uses]
Treatment of mild-to-moderate phenylketonuria (PKU). | [Definition]
ChEBI: Sapropterin is a tetrahydropterin that is 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one in which a hydrogen at position 6 is substituted by a 1,2-dihydroxypropyl group (6R,1'R,2'S-enantiomer). It has a role as a coenzyme, a diagnostic agent, a human metabolite and a cofactor. | [IC 50]
Human Endogenous Metabolite |
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