| Identification | Back Directory | [Name]
4-iodophthalic acid | [CAS]
6301-60-6 | [Synonyms]
Einecs 228-594-9
4-iodophthalic acid
4-Iodo-1,2-benzenedicarboxylic acid
1,2-BENZENEDICARBOXYLIC ACID,4-IODO | [EINECS(EC#)]
228-594-9 | [Molecular Formula]
C8H5IO4 | [MOL File]
6301-60-6.mol | [Molecular Weight]
292.03 |
| Chemical Properties | Back Directory | [Melting point ]
180-184 °C | [Boiling point ]
431.1±40.0 °C(Predicted) | [density ]
2.138±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [pka]
2.90±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 16, p. 1275, 1951 DOI: 10.1021/jo50002a014 | [Synthesis]
The general procedure for the synthesis of 4-iodophthalic acid from 3,4-dimethyl iodobenzene was as follows: 3,4-dimethyl iodobenzene (31 mL, 0.22 mol) was co-dissolved with pyridine (125 mL) in water (375 mL), and potassium permanganate (205 g, 1.3 mol) was slowly added at 60°C and reacted for 16 h under continuous stirring. After completion of the reaction, the temperature was maintained at 60°C and the filtrate was filtered through diatomaceous earth to remove solid impurities. After cooling the filtrate to room temperature, it was acidified by adjusting the pH to 2 with 6N hydrochloric acid and subsequently extracted with ethyl acetate. After purification by column chromatography, the target product 4-iodophthalic acid (44 g, 69% yield) was concentrated. | [References]
[1] Patent: KR2015/60183, 2015, A. Location in patent: Paragraph 0101; 0102; 0103
[2] European Journal of Organic Chemistry, 2015, vol. 2015, # 27, p. 5919 - 5924 |
|
|