630122-37-1

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630122-37-1 Structure

Identification	Back Directory
[Name] AFG206
[CAS] 630122-37-1
[Synonyms] AFG206 Urea, N-(4-ethylphenyl)-N'-[4-(4-pyridinyloxy)phenyl]-
[Molecular Formula] C20H19N3O2
[MOL File] 630122-37-1.mol
[Molecular Weight] 333.38

Hazard Information	Back Directory
[Description] AFG206 is the novel first-generation "type II" FLT3 inhibitor.
[Uses] AFG206 is a first-generation ATP competitive “type II” FLT3 inhibitor. AFG206 potently inhibits cell proliferation (IC50 around 0.1 μM) via induction of Apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells. AFG206 is promising for research of acute myeloid leukemia[1].
[References] [1] Weisberg E, et al. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 Oct;1(10):1021-32. DOI:10.1177/1947601910396505

630122-37-1 suppliers list

Company Name:	Suzhou Zhixin Biotechnology Co., Ltd.
Tel:	0512-65118909 15162312715
Website:	http://www.szzxbio.com/

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