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AFG206 is the novel first-generation "type II" FLT3 inhibitor. | [Uses]
AFG206 is a first-generation ATP competitive “type II” FLT3 inhibitor. AFG206 potently inhibits cell proliferation (IC50 around 0.1 μM) via induction of Apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells. AFG206 is promising for research of acute myeloid leukemia[1]. | [References]
[1] Weisberg E, et al. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 Oct;1(10):1021-32. DOI:10.1177/1947601910396505 |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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