| Identification | Back Directory | [Name]
anitrazafen | [CAS]
63119-27-7 | [Synonyms]
LY-122512
anitrazafen
5,6-Bis(4-methoxyphenyl)-3-methyl-1,2,4-triazine
5,6-Bis(p-methoxyphenyl)-3-methyl-1,2,4-triazine
1,2,4-Triazine, 5,6-bis(4-methoxyphenyl)-3-methyl- | [Molecular Formula]
C18H17N3O2 | [MDL Number]
MFCD00866012 | [MOL File]
63119-27-7.mol | [Molecular Weight]
307.35 |
| Chemical Properties | Back Directory | [Boiling point ]
482.8±55.0 °C(Predicted) | [density ]
1.164±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
1.85±0.63(Predicted) |
| Hazard Information | Back Directory | [Originator]
Lilly 122512,Eli Lilly | [Uses]
Anti-inflammatory (topical). | [Manufacturing Process]
Preparation of 5,6-bis(4-methoxyphenyl)-3-methyl-1,2,4-triazine:
(A) 3-Hydroxy-5,6-bis(4-methoxyphenyl)-1,2,4-triazine 2 moles, 540 g of
anisil (4,4'-dimethoxybenzil), 222 g (2 moles) of semicarbazide hydrochloride,
180 g (2.2 moles) of sodium acetate, and 2.5 liters of acetic acid were heated
at reflux overnight. The cooled reaction mixture was poured into 5 liters of
water. The crude solid product was collected by filtration, washed with water,
and recrystallized from acetic acid, giving 434 g of 3-hydroxy-5,6-bis(4-
methoxyphenyl)-1,2,4-triazine; MP: about 272°-274°C.
(B) 3-Chloro-5,6-bis(4-methoxyphenyl)-1,2,4-triazine:
10 grams of 3-hydroxy-5,6-bis(4-methoxyphenyl)-1,2,4-triazine and 50 ml of
phosphorous oxychloride were heated at reflux for 1.5 hours. The cooled
mixture was poured onto crushed ice and the resultant mixture was extracted
with diethyl ether. The extract was washed successively with 2% sodium
hydroxide and water until the washings were neutral. The ether extract was
dried over anhydrous sodium sulfate and evaporated. The residue was taken
up in ether, filtered, and the filtrate was evaporated to yield 9.0 g of 3-chloro-
5,6-bis(4-methoxyphenyl)-1,2,4-triazine; MP: about 130°-132°C.
(C) 5,6-Bis(4-methoxyphenyl)-3-methyl-1,2,4-triazine:
To a slurry of 11.7 g (0.33 mole) of methyltriphenylphosphonium bromide in
150 ml of dry tetrahydrofuran at -35°C was added, over a 15-minute period,
20 ml (0.033 mole) of n-butyl lithium. The reaction mixture was stirred for
one hour. To the reaction mixture at -35° to -40°C was added over a 10-
minute period a solution of 5.7 g (0.0165 mole) of 3-chloro-5,6-bis(4-
methoxyphenyl)-1,2,4-triazine in 50 ml of tetrahydrofuran. The reaction
mixture was allowed to warm to ambient temperature and was stirred
overnight. A solution of 1.05 g (0.0165 mole) of sodium carbonate in 50 ml of
water was added dropwise to the reaction mixture which then was heated at
reflux for three hours. The reaction mixture was cooled, poured over ice, and
extracted with diethyl ether. The diethyl ether extract was washed with water,
dried over anhydrous sodium sulfate, and concentrated. The concentrate was
chromatographed over silica gel, with three fractions being collected. After
evaporation of solvent, the third fraction solidified; MP: about 109°-113°C.
The solid was identified as 5,6-bis(4-methoxyphenyl)-3-methyl-1,2,4-triazine
by nuclear magnetic resonance analysis, mass spectrographic analysis, and
elemental microanalysis. | [Therapeutic Function]
Antiinflammatory | [in vivo]
Anitrazafen is a topically effective antiinflammatory agent. The disposition of 14C in normal and in bile-duct cannulated rats after oral administration of a single dose of 25 mg/kg of [3-14C]Anitrazafen shows the drug to be well absorbed from the gastro-intestinal tract and biliary excretion to be the major route of elimination of drug and/or metabolites. Plasma concentrations of total 14C after subcutaneous administration of [3-14C]Anitrazafen in corn oil solution are about one half those found after oral administration[1]. | [storage]
Store at -20°C |
|
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|