| Identification | Back Directory | [Name]
4-(cyclohexylsulfamoyl)benzoic acid | [CAS]
6314-70-1 | [Synonyms]
NSC23005
NSC23005 free acid
4-(N-Cyclohexylsulfamoyl)benzoic acid | [Molecular Formula]
C13H17NO4S | [MDL Number]
MFCD02573102 | [MOL File]
6314-70-1.mol | [Molecular Weight]
283.34 |
| Chemical Properties | Back Directory | [Melting point ]
259-260 °C | [Boiling point ]
473.4±47.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.54±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
NSC23005 is a p18INK inhibitor. NSC23005 potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM). | [Uses]
INK4C-IN-2 (Compound 40) is the inhibitor for INK4C (also known as p18) and the activator for CDK4/6. INK4C-IN-2 increases the number and expansion capacity of mouse and human hematopoietic stem cells (HSCs) with EC50 of 5.21 nM, promotes the self-renewal and multilineage differentiation of HSCs. INK4C-IN-2 improves the expansion and long-term hematopoietic reconstruction ability of HSCs in mouse bone marrow transplantation model[1]. | [References]
[1] Xie XQ, et al., Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci Rep. 2015 Dec 18;5:18115. DOI:10.1038/srep18115 |
|
|