| Identification | Back Directory | [Name]
KW-6055 | [CAS]
63233-46-5 | [Synonyms]
KW-6055
Butanamide, N-[3-nitro-4-(2-pyridinylmethyl)phenyl]- | [Molecular Formula]
C16H17N3O3 | [MDL Number]
MFCD00883670 | [MOL File]
63233-46-5.mol | [Molecular Weight]
299.32 |
| Hazard Information | Back Directory | [Uses]
KW-6055 is a benzylpyridine derivative with anti-amnesic effects. KW-6055 can increase the level of ACh in the brain cholinergic system and stimulate cholinergic neurons. | [in vivo]
KW-6055 is a benzylpyridine derivative and has anti-amnesic activity. KW-6055 (40, 160 mg/kg, p.o.) increases the extracellular level of ACh in normal rats (257±23, 202±24%). In basal forebrain-lesioned rats, KW-6055 (40 mg/kg, p.o.) significantly increases the extracellular level of ACh (251±22%) for more than 2 hr, which is longer than in normal rats[1]. | [References]
[1] Kurokawa M, et al. [Effects of KW-6055, a novel benzylpyridine derivative, on central cholinergic systems]. Nihon Yakurigaku Zasshi. 1992 Jun;99(6):435-43. Japanese. DOI:10.1254/fpj.99.435
[2] Kurokawa M, et al. Effects of KW-6055, a novel benzylpyridine derivative, on central cholinergic systems. Nihon Yakurigaku Zasshi. 1992 Jun;99(6):435-43. DOI:10.1254/fpj.99.435 |
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