| Identification | Back Directory | [Name]
H-ALPHA-ME-D-PRO-OH | [CAS]
63399-77-9 | [Synonyms]
EOS-61196
α-Me-D-Pro-OH
H-a-Me-D-Pro-OH
D-5-Methylproline
2-methyl-D-proline
(R)-2-Methylproline
H-ALPHA-ME-D-PRO-OH
H-a-Methyl-D-proline
(R)-a-Methyl-proline
D-Proline, 2-methyl-
Alpha-Methyl-D-Pro-OH
D-ALPHA-METHYLPROLINE
ALPHA-METHYL-D-PROLINE
H-alpha-Methyl-D-proline
D-Proline, 2-methyl- (9CI)
2-Methyl-D-proline hydroc...
H-ALPHA-ME-D-PRO-OH USP/EP/BP
2-Methyl-D-proline hydrochloride
2-methyl-D-proline(SALTDATA: HCl)
(R)-2-Methylproline Hydrochloride
(R)-2-Methylproline Hydrochloride, ≥98%
(R)-2-Methylpyrrolidine-2-carboxylicaci
(R)-2-Methylpyrrolidine-2-carboxylic acid
(2R)-2-methylpyrrolidine-2-carboxylic acid
alpha-Methyl-D-proline, (R)-a-Methyl-proline
(2r,5r)-5-Methylpyrrolidine-2-Carboxylic Acid | [EINECS(EC#)]
2017-001-1 | [Molecular Formula]
C6H11NO2 | [MDL Number]
MFCD08274534 | [MOL File]
63399-77-9.mol | [Molecular Weight]
129.16 |
| Chemical Properties | Back Directory | [Melting point ]
340℃ (DEC.) | [Boiling point ]
241.9±33.0 °C(Predicted) | [density ]
1.119 | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
powder | [pka]
2.44±0.20(Predicted) | [color ]
White | [Optical Rotation]
76.369°(C=0.01g/ml MEOH) |
| Hazard Information | Back Directory | [Uses]
(R)-2-Methyl Proline is a derivative of D-Proline (P755990) which is used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C. | [Synthesis]
The general procedure for the synthesis of (S)-2-methylproline and (R)-2-methylpyrrolidine-2-carboxylic acid from the compounds (CAS: 848488-83-5) is as follows: (R)-α-methylproline amide (0.40 g, 58% purity, 1.78 mmol) prepared in Reference Example 4 was added to a reaction flask with 6 M hydrochloric acid (2 mL) and stirred at 90°C for The reaction was carried out for 4 hours. Upon completion of the reaction, the product was analyzed by high performance liquid chromatography (HPLC) to confirm the presence of (R)-α-methylproline (204 mg, 1.58 mmol) in 90% yield and 89% ee optical purity. | [References]
[1] Patent: EP2716629, 2014, A1. Location in patent: Paragraph 0208; 0209
[2] Patent: JP5959417, 2016, B2. Location in patent: Paragraph 0175 |
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