| Identification | Back Directory | [Name]
1-(4-tert-butylbenzyl)-3-nitro-1H-1,2,4-triazole | [CAS]
634167-64-9 | [Synonyms]
DprE1-IN-377790
1-(4-tert-butylbenzyl)-3-nitro-1H-1,2,4-triazole | [Molecular Formula]
C13H16N4O2 | [MOL File]
634167-64-9.mol | [Molecular Weight]
260.292 |
| Hazard Information | Back Directory | [Description]
DprE1-IN-377790 is a novel DprE1 inhibitor, killing M. tuberculosis. | [Uses]
DprE1-IN-12 (compound 377790) is a covalent and DprE1 inhibitors and shows great activity against M. tuberculosis with an IC50 of 0.5 μM[1]. | [References]
[1] Gawad J, et al. Decaprenyl-phosphoryl-ribose 2'-epimerase (DprE1): challenging target for antitubercular drug discovery. Chem Cent J. 2018;12(1):72. Published 2018 Jun 23. DOI:10.1186/s13065-018-0441-2 |
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