| Identification | Back Directory | [Name]
3,5,9-Undecatrienoic acid, 2-ethylidene-11-[(1R,5R)-4-hydroxy-4-methyl-2-oxo-6-oxa-3-azabicyclo[3.1.0]hex-1-yl]-4,10-dimethyl-11-oxo-, 1,1-dimethylethyl ester, (2E,3E,5E,9E)- | [CAS]
634589-47-2 | [Synonyms]
3,5,9-Undecatrienoic acid, 2-ethylidene-11-[(1R,5R)-4-hydroxy-4-methyl-2-oxo-6-oxa-3-azabicyclo[3.1.0]hex-1-yl]-4,10-dimethyl-11-oxo-, 1,1-dimethylethyl ester, (2E,3E,5E,9E)- | [Molecular Formula]
C24H33NO6 | [MOL File]
634589-47-2.mol | [Molecular Weight]
431.52 |
| Hazard Information | Back Directory | [Uses]
ETB is a potent Hsp60 chaperone activity inhibitor. ETB blockes the chaperone activities of the wild-type protein and of the C237A and C447A mutant proteins. ETB binds to Hsp60 Cys442 and shows the resistance of the C442A mutant to ETB inhibition[1]. | [References]
[1] Nagumo Y, et al. Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity. Biochem J. 2005 May 1;387(Pt 3):835-40. DOI:10.1042/BJ20041355 |
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