| Identification | Back Directory | [Name]
4-AMINO-2,6-DIFLUOROPYRIDINE | [CAS]
63489-58-7 | [Synonyms]
6-difluoropyridin-4-aMine
2,6-difluoropyridin-4-aMine
2,6-difluoro-4-PyridinaMine
4-AMINO-2,6-DIFLUOROPYRIDINE
2,,6-difluoro-4-aminopyridine
4-Pyridinamine, 2,6-difluoro-
4-Amino-2,6-difluoropyridine 97%
4-Pyridinamine,2,6-difluoro-(9CI)
4-AMINO-2,6-DIFLUOROPYRIDINE ISO 9001：2015 REACH | [EINECS(EC#)]
200-589-5 | [Molecular Formula]
C5H4F2N2 | [MDL Number]
MFCD08436089 | [MOL File]
63489-58-7.mol | [Molecular Weight]
130.1 |
| Chemical Properties | Back Directory | [Melting point ]
124-125 | [Boiling point ]
267.8±35.0 °C(Predicted) | [density ]
1.393±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
solid | [pka]
-0.33±0.10(Predicted) | [color ]
Pale yellow | [InChI]
InChI=1S/C5H4F2N2/c6-4-1-3(8)2-5(7)9-4/h1-2H,(H2,8,9) | [InChIKey]
OWXBXLGJIFPPMS-UHFFFAOYSA-N | [SMILES]
C1(F)=NC(F)=CC(N)=C1 | [CAS DataBase Reference]
63489-58-7 |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 30, p. 340, 1987 DOI: 10.1021/jm00385a016 | [Synthesis]
In a 500 mL autoclave, 49.8 g (0.25 mol) of 2,6-difluoro-3,5-dichloro-4-aminopyridine, 200 mL of ethanol, 5.61 g (0.55 mol) of triethylamine, and 10.0 g of 10% palladium carbon catalyst were added. The reaction system was maintained at 25 °C and a hydrogen pressure of 0.46 MPa was applied and the reaction lasted for 24 hours. Upon completion of the reaction, the system was cooled and the hydrogen pressure was slowly released. The catalyst was removed by diafiltration followed by distillation under reduced pressure to remove the solvent. The crude product was purified by column chromatography using petroleum ether/ethyl acetate (3:1 v/v) as eluent. The final product was 20.6 g of 2,6-difluoro-4-aminopyridine as a white solid, which was determined to be 99.7% pure by liquid chromatographic normalization in 63.5% yield. | [References]
[1] Journal of Medicinal Chemistry, 1987, vol. 30, # 2, p. 340 - 347
[2] Patent: CN104610250, 2017, B. Location in patent: Paragraph 0076; 0077; 0079 |
|
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
| Company Name: |
Cochemical Ltd.
|
| Telephone: |
029-86115547 17791676824 |
| Website: |
http://www.cochemical.com |
| Company Name: |
Wuxi AppTec
|
| Telephone: |
022-59987777 13552403979 |
| Website: |
www.labnetwork.com |
|
Tags:o-Phthalaldehyde is a pale yellow crystalline solid.
o-Phthalaldehyde is mainly used as a high-level disinfectant (a low-temperature chemical method) for heat-sensitive medical and dental equipment such as endoscopes and thermometers; in recent years, it has gained popularity as a safe and better alternative to glutaraldehyde.
There are some researches show, pH7.5 contains the sterilizing agent of o-phthalaldehyde 0.5%, and its sterilizing power, sterilization speed, stability and toxicity all are better than glutaraldehyde, can kill mycobacterium in the 5min, the bacterium number reduces by 5 logarithmic value, and o-phthalaldehyde is very stable, tasteless in pH3～9 scopes, non-stimulated to human nose, eye mucosa, and need not activate before using, various materials are had good consistency, have tangible microbiocidal activity.
Related Product Information
|