| Identification | Back Directory | [Name]
NICOTINIC ACID HYDROCHLORIDE | [CAS]
636-79-3 | [Synonyms]
Niacin hydrochloride
NICOTINIC ACID HYDROCHLORIDE
Pyridine-3-carboxylic acid hydrochloride | [Molecular Formula]
C6H6ClNO2 | [MDL Number]
MFCD00152661 | [MOL File]
636-79-3.mol | [Molecular Weight]
159.57 |
| Hazard Information | Back Directory | [Uses]
Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases[1][2]. | [in vivo]
Niacin hydrochloride (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice[3].
| Animal Model: | Male C57BL/6 mice[3] | | Dosage: | 3-300 mg/kg | | Administration: | Subcutaneous injection; once | | Result: | Induced vasodilation in a dose-dependent manner. |
| [IC 50]
Microbial Metabolite; Human Endogenous Metabolite | [References]
[1] Areeg M Almubarak, et al. Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos. Theriogenology. 2021 Jul 15;169:36-46. doi: 10.1016/j.theriogenology.2021.04.005. Epub 2021 Apr 18. DOI:10.1016/j.theriogenology.2021.04.005
[2] Nobuhiro Hirakawa, et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci Biotechnol Biochem. 2005 Mar;69(3):653-8. DOI:10.1271/bbb.69.653
[3] Kang Cheng, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7. DOI:10.1073/pnas.0601574103 |
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