| Identification | Back Directory | [Name]
(+)-(s)-n-Methylsulfonylphenylalanyl chloride | [CAS]
63640-54-0 | [Synonyms]
(+)-(s)-n-Methylsulfonylphenylalanyl chloride
Benzenepropanoyl chloride, α-[(methylsulfonyl)amino]-, (αS)- | [Molecular Formula]
C10H12ClNO3S | [MDL Number]
MFCD09265482 | [MOL File]
63640-54-0.mol | [Molecular Weight]
261.73 |
| Chemical Properties | Back Directory | [alpha ]
[α]20D +4.3° (c 1.6, THF) | [Boiling point ]
402.5±55.0 °C(Predicted) | [density ]
1.349±0.06 g/cm3(Predicted) | [solubility ]
readily sol THF, benzene, ether | [pka]
8.68±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
(+)-(s)-n-Methylsulfonylphenylalanyl chloride is used as a chiral reagent for the resolution of racemic alcohols via separation of the corresponding diastereomeric esters.
| [Preparation]
(+)-(s)-n-Methylsulfonylphenylalanyl chloride is prepared from (S)-phenylalanine by reaction with Methanesulfonyl Chloride, followed by Phosphorus(V) Chloride.
| [storage]
(+)-(s)-n-Methylsulfonylphenylalanyl chloride is best if prepared immediately prior to use. Can be stored at 0 °C under nitrogen for several days without appreciable decomposition.
| [Purification Methods]
(+)-(s)-n-Methylsulfonylphenylalanyl chloride can be recrystallized from hexane/ether.
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