| Identification | Back Directory | [Name]
MOSAPRIDE CITRATE DIHYDRATE | [CAS]
636582-62-2 | [Synonyms]
Mosapride dihydrate citrate
MOSAPRIDE CITRATE DIHYDRATE USP/EP/BP
Mosapride citrate salt dihydrate
4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl ]-2-morpholinyl]methyl]benzamide citrate dihydrate
4-AMino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)Methyl]-2-Morpholinyl]Methyl]benzaMide 2-Hydroxy-1,2,3-propanetricarboxylate Hydrate | [Molecular Formula]
C27H33ClFN3O10 | [MDL Number]
MFCD00874415 | [MOL File]
636582-62-2.mol | [Molecular Weight]
614.016 |
| Chemical Properties | Back Directory | [Melting point ]
112-114°C | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥5mg/mL | [form ]
solid | [color ]
White to off-white | [InChIKey]
HUZTYZBFZKRPFG-UHFFFAOYSA-N | [SMILES]
O.O.OC(=O)CC(O)(CC(O)=O)C(O)=O.CCOc1cc(N)c(Cl)cc1C(=O)NCC2CN(CCO2)Cc3ccc(F)cc3 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
41 | [Safety Statements ]
26 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Dam. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A selective 5-HT4 receptor agonist. Gastroprokinetic. | [Definition]
ChEBI: Mosapride citrate dihydrate is a hydrate. | [Biochem/physiol Actions]
Mosapride is found effective against chronic gastritis, functional dyspepsia and gastro-oesophageal reflux disease. It is useful in treating many other symptoms associated with gastrointestinal disorders. Mosapride is known to improve digestive motility. | [in vivo]
Mosapride (Intravenous injection;0.3-3 mg/kg) dose-dependently increases the antral motor activity in conscious dogs which indicates that mosapride selectively stimulates upper gastrointestinal motility[2]. | Animal Model: | Beagle dogs[2] | | Dosage: | 0.3-3 mg/kg | | Administration: | Intravenous injection; 0.3-3 mg/kg | | Result: | Increased the antral motor activity dose-dependently in conscious dogs. |
| [IC 50]
5-HT4 Receptor; Kv4.3: 15.2 μM (IC50) |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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