| Identification | Back Directory | [Name]
R(+)-Baclofen.Hydrochloride | [CAS]
63701-55-3 | [Synonyms]
R(+)-BACLOFEN HCL
STX-209 HYDROCHLORIDE
d-baclofenhydrochloride
Arbaclofen hydrochloride
R(+)-BACLOFEN HYDROCHLORIDE
(+)-Baclofen (hydrochloride)
Arbaclofen hydrochloride salt
(r)-baclofenmonohydrochloride
Baclofen (R)-(+)- hydrochloride
R(+)-BACLOFENHYDROCHLORIDE(FORR&DONLY)
R(+)-4-AMINO-3-(4-CHLOROPHENYL)BUTANOIC ACID HCL
(+)-r-3-(p-chlorophenyl)-4-aminobutanoicacidhydrochloride
R(+)-BETA-(AMINOMETHYL)-4-CHLOROBENZENEPROPANOIC ACID HCL
R(+)-4-Amino-3-(4-chlorophenyl)butanoic acid hydrochloride
R(+)--(Aminomethyl(±)--(Aminomethyl)-4-Chlorobenzenepropanoic
R(+)-b-(Aminomethyl()-b-(Aminomethyl)-4-Chlorobenzenepropanoic
beta-(aminomethyl)-p-chloro-,hydrochloride,(r)-hydrocinnamicaci
r(+)-β-(aminomethyl)-4-chlorobenzenepropanoic acid hydrochloride
beta-(aminomethyl)-4-chloro-,hydrochloride,(r)-benzenepropanoicaci
R(+)-BETA-(AMINOMETHYL)-4-CHLOROBENZENEPROPANOIC ACID HYDROCHLORIDE | [Molecular Formula]
C10H13Cl2NO2 | [MDL Number]
MFCD00078579 | [MOL File]
63701-55-3.mol | [Molecular Weight]
250.12 |
| Chemical Properties | Back Directory | [Melting point ]
220～222℃ | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: >20 mg/mL
| [form ]
solid
| [color ]
white
| [Optical Rotation]
[α]28/D +3.8°, c = 0.9 in methanol(lit.) | [InChI]
1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1 | [InChIKey]
WMNUVYYLMCMHLU-QRPNPIFTSA-N | [SMILES]
Cl[H].NC[C@H](CC(O)=O)c1ccc(Cl)cc1 |
| Hazard Information | Back Directory | [Uses]
R(+)-Baclofen.Hydrochloride is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.
| [Biochem/physiol Actions]
R(+)-Baclofen is a GABAB receptor agonist; more active enantiomer; skeletal muscle relaxant. | [in vivo]
(R)-Baclofen hydrochloride (STX 209 hydrochloride) suppresses audiogenic seizures in the Fmr1-knockout mouse on the seizure-resistant C57BL/6 background with an effective dose of 1 mg/kg[3].
Acute intraperitoneal administration of (R)-Baclofen hydrochloride significantly reduces the percent of mice displaying seizures (seizure incidence), with a minimum effective dose (MED) of 1.5 mg/kg[3]. |
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