| Identification | Back Directory | [Name]
3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE | [CAS]
637031-93-7 | [Synonyms]
3,3-Difluorocyclobutanami...
3,3-difluorocyclobutanaMine hcl
(3,3-difluorocyclobutyl)azanium
3,3-Difluoro-cyclobutylamine HCl salt
3,3-DIFLUOROCYCLOBUTAMINE HYDROCHLORIDE
3,3-Diflurocyclobutanamine hydrochloride
3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE
(3,3-Difluorocyclobutyl)aMine Hydrochloride
3,3-difluorocyclobutan-1-aMine hydrochloride
3,3-Difluorocyclobutaneamine (hydrochloride)
Cyclobutanamine, 3,3-difluoro-, hydrochloride
3,3-Difluorocyclobutanamine hydrochloride, >=95%
CyclobutanaMine, 3,3-difluoro-, hydrochloride (1:1)
3,3-difluorocyclobutanamine hydrochloride （Ivosidenib Intermediate） | [EINECS(EC#)]
810-267-2 | [Molecular Formula]
C4H7F2N.HCl | [MDL Number]
MFCD10001382 | [MOL File]
637031-93-7.mol | [Molecular Weight]
143.56 |
| Chemical Properties | Back Directory | [Melting point ]
296 °C | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [InChI]
InChI=1S/C4H7F2N.ClH/c5-4(6)1-3(7)2-4;/h3H,1-2,7H2;1H | [InChIKey]
WLXXTHPAORBNIG-UHFFFAOYSA-N | [SMILES]
FC1(CC(N)C1)F.Cl |
| Hazard Information | Back Directory | [Uses]
3,3-Difluorocyclobutanamine hydrochloride is used in the preparation of piperazinyl antiviral agents as well as kinase inhibitors.
| [Synthesis]
Step C: Synthesis of 3,3-difluorocyclobutylamine hydrochloride. A mixture of benzyl (3,3-difluorocyclobutyl)carbamate (1.47 g, 6.1 mmol) and 10% Pd/C (1 g) in methanol (20 mL) was subjected to a hydrogen atmosphere (1 atm) and stirred overnight at room temperature. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and washed with methanol. Concentrated hydrochloric acid (2 mL) was added to the filtrate, followed by evaporation of the solvent under vacuum to afford the target product 3,3-difluorocyclobutanamine hydrochloride (0.8 g, 85% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.60 (m, 3H), 3.64 (m, 1H), 2.89 (m, 4H). | [References]
[1] Patent: WO2012/9678, 2012, A1. Location in patent: Page/Page column 210
[2] Patent: US2013/303524, 2013, A1. Location in patent: Paragraph 0413-0414 |
|
|