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637348-81-3

637348-81-3 Structure

637348-81-3 Structure
IdentificationBack Directory
[Name]

3-Bromo-2-hydroxy-5-iodopyridine
[CAS]

637348-81-3
[Synonyms]

3-broMo-5-iodopyridin-2-ol
3-bromo-5-iodo-2(1H)-Pyridinone
3-Bromo-5-iodo-1H-pyridin-2-one
3-bromo-5-iodopyridin-2(1H)-one
3-Bromo-2-hydroxy-5-iodopyridine
3-BroMo-5-iodo-2-hydroxypyridine
2(1H)-Pyridinone, 3-bromo-5-iodo-
[Molecular Formula]

C5H3BrINO
[MDL Number]

MFCD11044276
[MOL File]

637348-81-3.mol
[Molecular Weight]

299.89
Chemical PropertiesBack Directory
[Boiling point ]

308.0±42.0 °C(Predicted)
[density ]

2.55±0.1 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,Room temperature
[pka]

8.66±0.10(Predicted)
[Appearance]

Off-white to gray Solid
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H319-H335-H302+H312+H332-H315
[Precautionary statements ]

P280-P305+P351+P338-P362+P364
[HS Code ]

2933399990
Spectrum DetailBack Directory
[Spectrum Detail]

3-Bromo-2-hydroxy-5-iodopyridine(637348-81-3)1HNMR
Hazard InformationBack Directory
[Synthesis]

3-Bromo-2-hydroxypyridine

13466-43-8

3-Bromo-2-hydroxy-5-iodopyridine

637348-81-3

The general procedure for the synthesis of 3-bromo-2-hydroxy-5-iodopyridine from 3-bromo-2-hydroxypyridine is as follows: Example 142a Synthesis of 3-bromo-5-iodopyridin-2-ol In a 100 mL single-necked round-bottomed flask equipped with a magnetic stirrer, acetonitrile (50 mL), trifluoroacetic acid (TFA, 10 mL), 3-bromo-2-hydroxypyridine (4.0 g, 23.12 mmol), and N-iodosuccinimide (NIS, 5.2 g, 23.12 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 15 hours. Upon completion of the reaction, the mixture was diluted with 100 mL of water and the resulting white solid was collected by filtration to afford the target product 3-bromo-5-iodopyridin-2-ol (142a, 6.6 g, 96% yield). Mass spectrometry analysis (MS-ESI): [M + H]+ m/z 300.

[References]

[1] Patent: US2013/116246, 2013, A1. Location in patent: Paragraph 0467
[2] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0844; 0845
[3] Synlett, 2003, # 11, p. 1678 - 1682
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 9, p. 2157 - 2165
[5] Patent: WO2007/126733, 2007, A2. Location in patent: Page/Page column 33; 46-47
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