| Identification | Back Directory | [Name]
hygromycin A | [CAS]
6379-56-2 | [Synonyms]
Homomycin
Hygromycin
Homomycin A
hygromycin A
Antibiotic WS-1627B
5-Deoxy-5-[[(2E)-3-[4-[(6-deoxy-β-D-arabino-5-hexosulofuranosyl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-propenyl]amino]-1-O,2-O-methylene-D-neo-inositol
D-neo-Inositol, 5-deoxy-5-[[(2E)-3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-propen-1-yl]amino]-1,2-O-methylene- | [EINECS(EC#)]
608-965-5 | [Molecular Formula]
C23H29NO12 | [MOL File]
6379-56-2.mol | [Molecular Weight]
511.477 |
| Chemical Properties | Back Directory | [Appearance]
White powder. Weakly acidic. Freely
soluble in water and alcohol. Produced by Streptomyces hygroscopicus. | [Melting point ]
105-109°; mp 110-112° (dec) (Chida) | [alpha ]
D25 -126° (c = 1 in water) | [Boiling point ]
925.5±65.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: 16 mg/mL,DMSO: 10 mg/mL,Ethanol: 12 mg/mL,PBS (pH 7.2): 10 mg/mL | [form ]
A solid | [pka]
8.9(at 25℃) | [color ]
White to light yellow | [InChIKey]
YQYJSBFKSSDGFO-MZHPCZETNA-N | [SMILES]
[C@H]12OCO[C@H]1[C@@H](O)[C@H](O)[C@H](NC(=O)/C(/C)=C/C1=CC=C(O[C@H]3[C@@H](O)[C@H](O)[C@@H](C(=O)C)O3)C(O)=C1)[C@@H]2O |&1:0,4,5,7,9,21,22,24,26,34,r| | [Uses]
Medicine (broad-spectrum antibiotic). | [CAS DataBase Reference]
6379-56-2 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder. Weakly acidic. Freely
soluble in water and alcohol. Produced by Streptomyces hygroscopicus. | [Definition]
ChEBI: A natural product found in Streptomyces species. | [Biological Activity]
Hygromycin A is an orally available antibiotic produced by Streptomyces hygroscopicus th at targets the ribosomal 23S rRNA. Hygromycin A is selectively taken up by nucleoside transporter specific to spirochete bacteria including Borreliella burgdorferiwhich causes Lyme disease. It clears B. burgdorferi infection in mice with lesser disruption of micron=biome than clinical antibiotics. | [in vivo]
Hygromycin A selectively kills Borrelia burgdorferi and has a favorable impact on the gut microbiota composition, leading to eubiosis[1]. | [storage]
-20°C |
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