| Identification | Back Directory | [Name]
4-Pyridinecarboxylic acid, 2-[[(phenylmethyl)amino]thioxomethyl]hydrazide | [CAS]
63932-07-0 | [Synonyms]
Anti-inflammatory agent 11
4-Pyridinecarboxylic acid, 2-[[(phenylmethyl)amino]thioxomethyl]hydrazide | [Molecular Formula]
C14H14N4OS | [MOL File]
63932-07-0.mol | [Molecular Weight]
286.35 |
| Hazard Information | Back Directory | [Uses]
Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research[1]. | [References]
[1] Calixto SD, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506. DOI:10.1016/j.bmc.2021.116506 |
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