| Identification | Back Directory | [Name]
3 5-DIFLUOROSALICYLALDEHYDE 97 | [CAS]
63954-77-8 | [Synonyms]
3,5-Difluoro-2-hydrox
3,5-Difluorosalicaldehyde
3 5-DIFLUOROSALICYLALDEHYDE 97
3,5-Difluorosalicylaldehyde 97%
3,5-difluoro-2-hydroxybenzaldehde
3,5-Difluoro-2-hydroxybenzaldehyde98%
Benzaldehyde, 3,5-difluoro-2-hydroxy-
3,5-Difluoro-2-hydroxybenzaldehyde 98%
3,5-Difluorosalicylaldehyde, 2,4-Difluoro-6-formylphenol | [EINECS(EC#)]
625-317-7 | [Molecular Formula]
C7H4F2O2 | [MDL Number]
MFCD06246883 | [MOL File]
63954-77-8.mol | [Molecular Weight]
158.1 |
| Chemical Properties | Back Directory | [Melting point ]
87-91 °C (lit.) | [Boiling point ]
181.9±35.0 °C(Predicted) | [density ]
1.464±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
solid | [pka]
6.94±0.23(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C7H4F2O2/c8-5-1-4(3-10)7(11)6(9)2-5/h1-3,11H | [InChIKey]
QGSAZWCEHUYVMW-UHFFFAOYSA-N | [SMILES]
C(=O)C1=CC(F)=CC(F)=C1O |
| Hazard Information | Back Directory | [Uses]
3,5-Difluorosalicylaldehyde may be used in the synthesis of Ni[CpFe(η5-C5H4)-C(O)CH=C(CH3)N-o-C6H4N=CH-(2-O,3,5-F2-C6H2)] (Cp = cyclopentyl) and Zn(salphenazine) complex. | [General Description]
3,5-Difluorosalicylaldehyde has been synthesized by employing 2,4-difluorophenol as a starting reagent. | [Synthesis]
Phosphoryl chloride (12 g, 77 mmol) was slowly added dropwise to anhydrous N,N-dimethylformamide (8.4 g, 0.12 mol) at 0 °C and under nitrogen protection while maintaining stirring. After the dropwise addition, the reaction mixture was continued to be stirred at this temperature for 30 min. Subsequently, a solution of N,N-dimethylformamide (50 mL) of 2,4-difluorophenol (5.0 g, 39 mmol) was slowly added dropwise to the above mixture. After completion of the dropwise addition, the reaction mixture was transferred to room temperature conditions with continuous stirring for 5 hours. Upon completion of the reaction, the reaction was carefully quenched with water and extracted with ethyl acetate (3 x 150 mL). The organic phases were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, and finally concentrated under reduced pressure to afford the target product 3,5-difluoro-2-hydroxybenzaldehyde (5.5 g, 90% yield) as a yellow oil. | [References]
[1] Patent: WO2015/66371, 2015, A1. Location in patent: Paragraph 00326-00327 |
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