| Identification | Back Directory | [Name]
Ro 04-5595 hydrochloride | [CAS]
64047-73-0 | [Synonyms]
Ro 04-5595
Ro 04 5595 hydrochloride,Ro 045595 hydrochloride | [Molecular Formula]
C19H23Cl2NO2 | [MDL Number]
MFCD01717050 | [MOL File]
64047-73-0.mol | [Molecular Weight]
368.3 |
| Hazard Information | Back Directory | [Uses]
Ro 04-5595 Hydrochloride is a selective NMDA receptor inhibitor. | [in vivo]
Ro 04-5595 hydrochloride (5-20 mg/kg, i.p.) inhibits MA-induced locomotor stimulation in mice[2].
Ro 04-5595 hydrochloride (10?mg/kg, i.p., for 6 days) reduced AMPA to NMDA ratio in Cocaine self-administering rats[3].
| Animal Model: | Methamphetamine (MA) treated mice[1] | | Dosage: | 3-30 mg/kg | | Administration: | i.p., given 30?min before injection of MA (2?mg/kg, i.p.) | | Result: | Dose-dependently decreased MA-induced locomotor activity. |
| [IC 50]
GluN2B: 31 nM (Ki) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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