| Identification | Back Directory | [Name]
CAY10580 | [CAS]
64054-40-6 | [Synonyms]
CAY10580
CAY10580 Exclusive
CBWGHEDGUILASE-UHFFFAOYSA-N
2-(3-HYDROXYOCTYL)-5-OXO-1-PYRROLIDINEHEPTANOIC ACID
1-Pyrrolidineheptanoic acid, 2-(3-hydroxyoctyl)-5-oxo- | [Molecular Formula]
C19H35NO4 | [MDL Number]
MFCD11976917 | [MOL File]
64054-40-6.mol | [Molecular Weight]
341.49 |
| Chemical Properties | Back Directory | [Boiling point ]
534.4±25.0 °C(Predicted) | [density ]
1.049±0.06 g/cm3(Predicted) | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 2.5 mg/ml | [form ]
Liquid | [pka]
4.77±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid is an analog of PGE2. | [Uses]
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10580 is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and >3,000 nM, respectively). CAY10580 stimulates cAMP formation in excised mouse ovaries.[Cayman Chemical] | [Definition]
ChEBI:2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid is a pyrrolidin-2-one substituted by 6-carboxyhexyl and 3-hydroxyoctyl groups at positions 1 and 2, respectively. It is a potent prostaglandin EP4 receptor agonist (Ki=35 nM). It has a role as a prostaglandin receptor agonist. It is a member of pyrrolidin-2-ones, a hydroxy monocarboxylic acid and a secondary alcohol. | [in vivo]
CAY10580 (200 μg/kg body weight; i.p; daily for three weeks) effectively prevents diet-induced hypercholesterolemia, enhances endogenous bile acid synthesis and their fecal excretion[3]. | Animal Model: | Six-week old male EP4+/+ mice (Treating high fat diet-challenged mice)[3] | | Dosage: | 200 μg/kg body weight | | Administration: | Intraperitoneal injection; daily for remaining three weeks | | Result: | High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values.
|
| [IC 50]
EP4: 35 nM (Ki); EP2: 3000 nM (Ki); EP3: 2000 nM (Ki); EP1: >3000 nM (Ki) |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|