| Identification | Back Directory | [Name]
4-N-Maleimidobenzoic acid-NHS | [CAS]
64191-06-6 | [Synonyms]
RH02007
RH-02007
CCG40788
RH 02007
CCG 40788
CCG-40788
4-Mal-Bz-NHS
4-N-Maleimidobenzoic acid-NHS
4-MaleiMidobenzoic acid-NHS ester
2,5-dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate
2,5-Dioxo-1-pyrrolidinyl 4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)benzoate
1-(4-{[(2,5-Dioxopyrrolidin-1-yl)oxy]carbonyl}phenyl)-1H-pyrrole-2,5-dione
Benzoic acid, 4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C15H10N2O6 | [MDL Number]
MFCD01318593 | [MOL File]
64191-06-6.mol | [Molecular Weight]
314.25 |
| Chemical Properties | Back Directory | [Melting point ]
205-207 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3)) | [Boiling point ]
523.0±52.0 °C(Predicted) | [density ]
1.59±0.1 g/cm3(Predicted) | [pka]
-4.69±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
4-N-Maleimidobenzoicacid-NHS is a PEG linker that finds utility in bioconjugation endeavors and protein labeling ventures. Specifically designed for selective reaction with thiol groups, the maleimide group establishes covalent linkages, thereby facilitating the coupling of proteins, peptides, or diverse molecules to thiol-bearing biomolecules. The NHS ester is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic conditions to form a covalent bond. |
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