| Identification | Back Directory | [Name]
Indole alkaloid | [CAS]
642-18-2 | [Synonyms]
Aids002662
Aids-002662
3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19.alpha.-methyl-20.alpha.- oxayohimbanium
Oxayohimbanium,3,4,5,6,16,17-hexadehydro-16-(methoxycarbonyl)-19-methyl-, inner salt, (19a,20a)- | [Molecular Formula]
C21H20N2O3 | [MDL Number]
MFCD00083501 | [MOL File]
642-18-2.mol | [Molecular Weight]
348.4 |
| Hazard Information | Back Directory | [Definition]
ChEBI: Alstonine is an indole alkaloid with formula C21H20N2O3, isolated from several Rauvolfia species and exhibits antipsychotic activity. It has a role as an antipsychotic agent. It is a methyl ester, an organic heteropentacyclic compound, a zwitterion and an indole alkaloid. It is a conjugate base of an alstonine(1+). | [Biological Activity]
Alstonine is the main indole alkaloid compound of a botanical drug. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties. | [in vitro]
Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues. | [in vivo]
In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (ip) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg.
Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages.
Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells. |
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